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9 %~12 % Cr 钢 1

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M23C6 碳化物 1

显微结构 1

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蠕变强度 1

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Base editors: development and applications in biomedicine

《医学前沿（英文）》 2023年 第17卷 第3期   页码 359-387 doi: 10.1007/s11684-023-1013-y

摘要： Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system with an individual deaminase, enabling precise single-base substitution in DNA or RNA without generating a DNA double-strand break (DSB) or requiring donor DNA templates in living cells. Base editors offer more precise and secure genome-editing effects than other conventional artificial nuclease systems, such as CRISPR/Cas9, as the DSB induced by Cas9 will cause severe damage to the genome. Thus, base editors have important applications in the field of biomedicine, including gene function investigation, directed protein evolution, genetic lineage tracing, disease modeling, and gene therapy. Since the development of the two main base editors, cytosine base editors (CBEs) and adenine base editors (ABEs), scientists have developed more than 100 optimized base editors with improved editing efficiency, precision, specificity, targeting scope, and capacity to be delivered in vivo, greatly enhancing their application potential in biomedicine. Here, we review the recent development of base editors, summarize their applications in the biomedical field, and discuss future perspectives and challenges for therapeutic applications.

关键词： base editing     CBE     ABE     ADAR     DdCBE     disease model     therapeutic application    

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700 °C 及以上蒸汽温度下先进USC发电厂用耐热材料的研究和开发 Review

Fujio Abe

《工程（英文）》 2015年 第1卷 第2期   页码 211-224 doi: 10.15302/J-ENG-2015031

摘要：

欧洲、美国、日本已开展蒸汽温度为700 °C 及以上的先进超超临界(A-USC) 发电厂用材料开发项目，以实现更高能效和低二氧化碳排放量。近年来中国、印度等也开展了上述项目的开发和研究。这些项目涉及采用镍基合金更换马氏体9%~12%Cr 钢以用于最高温度的锅炉和涡轮部件，从而在700 °C 及以上温度下提供充足的蠕变强度。为尽量减少对昂贵的镍基合金的需求，马氏体9%~12%Cr 钢可用于A-USC 电厂中的次高温部件(最高温度不超过650 °C)。本文综述了A-USC 电厂厚型材锅炉和涡轮部件用镍基合金和马氏体9%~12%Cr 钢的研究和开发，主要关注高温下基底金属和焊缝的长期蠕变断裂强度、焊缝强度损失、蠕变疲劳性质和显微结构演化。

关键词： 镍基合金     9 %~12 % Cr 钢     蠕变强度     蠕变疲劳性质     焊缝     晶界     显微结构     &gamma     &prime     M23C6 碳化物    

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标题 作者 时间 类型 操作

Base editors: development and applications in biomedicine

期刊论文

700 °C 及以上蒸汽温度下先进USC发电厂用耐热材料的研究和开发

Fujio Abe

期刊论文